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Medplum vs Oystehr

Medplum and Oystehr both land on Depends.

Medplum

medplum.com

Depends
Confidence: Medium

Buy if you have engineers building a custom healthcare product and need HIPAA-compliant FHIR infrastructure.

Read the full report

Oystehr

oystehr.com

Depends
Confidence: Medium

Buy it if you have engineers building a custom healthcare product and want FHIR-native APIs with usage-based pricing.

Read the full report

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Medplum versus Oystehr
CompareMedplumOystehr
VerdictDependsDepends
Best forFunded startups building custom healthcare appsHealth-tech startups building custom EHRs
Who it's not forClinics wanting an out-of-box EHR . there is no finished productClinics without in-house engineers
PrivacyHIPAA-compliant platform, but multiple 2025-2026 CVEs (SSRF, OAuth secret exposure, privilege-escalation RCE) demand prompt patching.⁷HIPAA compliant and ONC Health IT certified per official docs; no public vulnerability findings in sources reviewed.
Support qualityNo support evidence in sourcesNo support evidence in sources reviewed
Public sentimentDevelopers praise Medplum's programmability and FHIR foundation; non-technical buyers should expect to build, not install.³Independent reviews are sparse but positive, praising the developer experience, API-friendliness, and interoperability.
Biggest gotchaSelf-hosting the open-source core means you own uptime, HIPAA controls, and patchingUsage-based billing scales with API volume; model per-call costs before committing.15

Pick Medplum when

  • Funded startups building custom healthcare apps
  • Engineering teams needing a FHIR backend
  • Tech-enabled clinics with in-house developers
  • Teams needing HIPAA infra without building from scratch

When Medplum is not a fit

  • Clinics wanting an out-of-box EHR . there is no finished product
  • Non-technical founders expecting a ready app
  • Small practices needing just scheduling or billing
  • Teams with no engineers to self-host or integrate

Pick Oystehr when

  • Health-tech startups building custom EHRs
  • Urgent care and telehealth platforms
  • Dev teams wanting FHIR-native APIs
  • Teams starting from open-source Ottehr

When Oystehr is not a fit

  • Clinics without in-house engineers
  • Anyone wanting turnkey, out-of-the-box EHR
  • Small practices needing billing and scheduling day one
  • Buyers wary of proprietary serverless lock-in

Sources

  1. Medplum Pricingmedplum.com
    official
  2. Medplum pricing: from $2,000/mo (Shyft)shyft.ai
    news
  3. Medplum Reviews . Elion Healthelion.health
    review
  4. Headless EHR Comparison: Medplum vs Healthie vs OpenEMRmindbowser.com
    review
  5. Stop building your own EHR: a CTO's intro to Medplumvintasoftware.com
    review
  6. Ro Case Studymedplum.com
    official
  7. CVE-2026-44506 . Rapid7rapid7.com
    security
  8. CVE-2026-49120 . SentinelOnesentinelone.com
    security
  9. GHSA-w852-7r27-32c6 . GitHub Advisorygithub.com
    security
  10. Medplum Revenue . GetLatkagetlatka.com
    news
  11. Medplum . Y Combinatorycombinator.com
    official
  12. Why Medplum Is Open Sourcemedplum.com
    official
  13. Reddit r/healthIT on Medplumreddit.com
    review
  14. Is Medplum HIPAA Compliant . Keragonkeragon.com
    security
  15. Usage-Based EHR Pricingoystehr.com
    official
  16. HIPAA . Oystehr & Ottehr Documentationdocs.oystehr.com
    security